Alemtuzumab following natalizumab in highly active paediatric-onset multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Intractable and highly active relapsing multiple sclerosis – role of alemtuzumab
Alemtuzumab is a humanized recombinant monoclonal antibody that was recently approved by the US Food and Drug Administration and the European Medicines Agency for the management of relapsing forms of multiple sclerosis (MS). It has been utilized for the management of chronic lymphocytic leukemia, bone marrow and renal transplantation, or graft versus host disease. Because of its immunomodulator...
متن کاملNatalizumab therapy for highly active pediatric multiple sclerosis.
IMPORTANCE Given the high frequency of failure of first-line therapies, there is an urgent need for second-line treatment strategies for pediatric patients with multiple sclerosis (MS). OBJECTIVE To report the use of natalizumab in pediatric MS. Natalizumab, a humanized monoclonal antibody targeting α4 integrin, is effective against active relapsing-remitting MS in adults. DESIGN Retrospect...
متن کاملOnset symptoms in paediatric multiple sclerosis.
INTRODUCTION Paediatric multiple sclerosis (MS) carries a relatively higher mortality and morbidity than adult MS. Paediatric MS symptoms and paraclinical findings at the first demyelinating event have never before been characterised in a Danish setting. The aim of this study was to compare symptoms and paraclinical findings at the first demyelinating event in paediatric MS with those of an adu...
متن کاملComparative efficacy of switching to natalizumab in active multiple sclerosis
OBJECTIVE To compare treatment efficacy and persistence in patients who switched to natalizumab versus those who switched between glatiramer acetate (GA) and interferon-beta (IFNβ) after an on-treatment relapse on IFNβ or GA using propensity score matched real-world datasets. METHODS Patients included were registered in MSBase or the TYSABRI Observational Program (TOP), had relapsed on IFNβ o...
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Alemtuzumab is a humanised anti-CD52 monoclonal antibody approved for use in active, relapsing multiple sclerosis (MS). Administration results in a rapid depletion of circulating lymphocytes with a subsequent beneficial immune reconstitution. Early open-label experience and recent clinical trials have demonstrated a dramatic effect on relapse rates as well as a positive effect on radiological d...
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ژورنال
عنوان ژورنال: Multiple Sclerosis Journal - Experimental, Translational and Clinical
سال: 2019
ISSN: 2055-2173,2055-2173
DOI: 10.1177/2055217319875471